Benzoyl chloride → N-(1,1-Dimethyl-2-hydroxyethyl)benzamide

HRID 426850노트

반응식

HRID 426850 반응식
[NH2:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].[C:7](Cl)(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>ClCCl>[C:7]([NH:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 7412Benzoyl chlorideHCID 118072-Amino-2-methyl-1-propanol

생성물 1

HCID 639965N-(1,1-Dimethyl-2-hydroxyethyl)benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a 250 ml dichloromethane solution containing 89 g (1.0 mol) 2-amino-2-methyl-1-propanol at 0° was added dropwise with stirring 70 g (0.5 mol) benzoyl chloride in 250 ml dichloromethane. The reaction mixture was warmed to room temperature and stirred for several hours. The 2-amino-2-methyl-1-propanol hydrochloride was removed from the reaction mixture by filtration and was thoroughly washed with dichloromethane. The filtrate and washings were combined and the dichloromethane removed under reduced pressure to afford 67.55 g (0.35 mol), 70%, 2-benzoylamino-2-methyl-1-propanol as a white solid, mp 80°-82°, sublimation at 75° (0.2 mm); ir (KBr) 1630 (c=o) cm-1 ; pmr (CDCl3) δ 1.50 (s, 6H), 3.67 (s, 2H), 5.27 (bs, 1H), 6.92 (bs, 1H) and 7.1-8.3 (m, 5H) ppm.

후처리

  1. additionwas added dropwise
  2. customThe 2-amino-2-methyl-1-propanol hydrochloride was removed from the reaction mixture by filtration
  3. washwas thoroughly washed with dichloromethane
  4. customthe dichloromethane removed under reduced pressure

출처 및 근거

ORD 기록
ord-dfce4f8b23a24a4db44efe712d86e5d6
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04171452

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