Ethanol → Trifluoromethyl toluidine

HRID 427004

반응식

HRID 427004 반응식
[NH2:1][C:2]1[C:3]([CH2:13]SC)=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:5]=[CH:6][C:7]=1Cl.C(O)C>[OH-].[K+].[Ni]>[NH2:1][C:2]1[C:3]([CH3:13])=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 702EthanolHCID 233529853-Amino-4-chloro-2-methylthiomethylbenzotrifluoride

생성물 1

HCID 2735932Trifluoromethyl toluidine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 14797Potassium Hydroxide용매

반응 조건

온도
70 °C

실험 절차

Dissolve 2 g. of 3-amino-4-chloro-2-methylthiomethylbenzotrifluoride in 50 ml. of 90% ethanol which is 1N in potassium hydroxide. Add 2 teaspoonsful of Raney nickel (W-2). Stir at 70° C. for 3 hours, cool and filter. Add 50 ml. of water and extract three times with hexane. Dry the combined organic extracts and evaporate to yield the title compound.

후처리

  1. dissolutionDissolve 2 g
  2. temperaturecool
  3. filtrationfilter
  4. additionAdd 50 ml
  5. extractionof water and extract three times with hexane
  6. customDry the combined organic extracts
  7. customevaporate

출처 및 근거

ORD 기록
ord-392def21d91848d499a8551560e39e13
출처 데이터셋
uspto-grants-1979_10
특허 번호
US04172095

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