Acetonitrile → 3-(4-(Acryloyloxy)butoxy)-2-hydroxypropyl 2-benzoylbenzoate

HRID 42733

반응식

HRID 42733 반응식
[C:1]([C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(#N)C.C([C:25]1C=C(C)C=[C:27](C(C)(C)C)[C:26]=1[OH:36])(C)(C)C.[OH:37][CH2:38][CH2:39][CH2:40][CH2:41][O:42][C:43](=[O:46])[CH:44]=[CH2:45].C(OCC1OC1)C1OC1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.CC(N(C)C)=O>[C:43]([O:42][CH2:41][CH2:40][CH2:39][CH2:38][O:37][CH2:25][CH:26]([OH:36])[CH2:27][O:12][C:11](=[O:13])[C:10]1[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=1[C:1](=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)(=[O:46])[CH:44]=[CH2:45]

참가 물질

7

반응물 4

HCID 6342AcetonitrileHCID 68132-Benzoylbenzoic AcidHCID 314042,6-Di-tert-butyl-4-methylphenolHCID 223231504-Hydroxybutylacrylate glycidylether

생성물 1

HCID 583255113-(4-(Acryloyloxy)butoxy)-2-hydroxypropyl 2-benzoylbenzoate

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 31374Dimethylacetamide용매

실험 절차

A reaction mixture containing 2-benzoyl benzoic acid (40.0 g, 0.1722 mol), acetonitrile (300 mL), dimethylacetamide (10 mL), tetrabutylammonium bromide (5.6 g, 17.22 mmol) and 2,6-di-tert-butyl-4-methylphenol (0.3 g, 1.4 mmol) was heated to reflux. At this temperature 4-hydroxybutylacrylate glycidylether (28.0 g, 140 mmol) was added and the mixture was allowed to stir at reflux temperature for 16 hours.

후처리

  1. temperaturewas heated to reflux
  2. temperatureat reflux temperature for 16 hours

출처 및 근거

ORD 기록
ord-320c13860a99488e881a36e355cfd6ef
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536217B2

연결된 노트

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