Potassium Hydroxide → 4-[3-(4-Carbamoylphenoxy)-1-pyrrolidinyl]pyridine

HRID 427458

반응식

HRID 427458 반응식
[C:1]([C:3]1[CH:20]=[CH:19][C:6]([O:7][CH:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:9]2)=[CH:5][CH:4]=1)#[N:2].[OH-:21].[K+]>C(O)(C)(C)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:7][CH:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:9]2)=[CH:19][CH:20]=1)(=[O:21])[NH2:2]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 183570874-[3-(4-Cyanophenoxy)-1-pyrrolidinyl]pyridine

생성물 1

HCID 183571004-[3-(4-Carbamoylphenoxy)-1-pyrrolidinyl]pyridine수율 57.8%

시약·촉매·용매 1

HCID 6386tert-Butanol용매

실험 절차

A mixture of 4-[3-(4-cyanophenoxy)-1-pyrrolidinyl]pyridine (269 mg) and powdered potassium hydroxide (568 mg) in t-butanol (10 ml), under an atmosphere of argon, was heated under reflux for 18 hours. The mixture was filtered hot. The filtercake was washed with water and ethanol to give 4-[3-(4-carbamoylphenoxy)-1-pyrrolidinyl]pyridine (166 mg) as a colourless solid, mp 298-300° C.

후처리

  1. temperatureunder an atmosphere of argon, was heated
  2. temperatureunder reflux for 18 hours
  3. filtrationThe mixture was filtered hot
  4. washThe filtercake was washed with water and ethanol

출처 및 근거

ORD 기록
ord-1c442b2f30054d8ab9cea61c32b9e4d3
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313127B1

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