Benzoyl Peroxide → 1-Bromo-2-(bromomethyl)-3-methylbenzene

HRID 427513

반응식

HRID 427513 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[CH3:9].[Br:10]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>ClC(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[CH2:9][Br:10]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 684723-Bromo-o-xylene

생성물 1

HCID 133583181-Bromo-2-(bromomethyl)-3-methylbenzene수율 45%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of 3-bromo-o-xylene (15 g, 81 mmol), N-bromo succinimid (15.1 g, 85.1 mmol), dibenzoylperoxid (0.65 g) and tetrachloromethane (150 ml) was refluxed for 5 hours. After filtration the filtrate was washed with sodium hydrogensulfite and water. The organic layer was dried over sodium sulfate and evaporated in vacuo. Chromatography (SiO2) (petroleum ether:ethyl acetate, 100:4) gave a 16.8 g fraction of a mixture containing 45% of the title compound. This mixture was used without further purification.

후처리

  1. temperaturewas refluxed for 5 hours
  2. filtrationAfter filtration the filtrate
  3. washwas washed with sodium hydrogensulfite and water
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. customevaporated in vacuo
  6. customChromatography (SiO2) (petroleum ether:ethyl acetate, 100:4) gave a 16.8 g fraction of a mixture

출처 및 근거

ORD 기록
ord-51db4384e25a49baa3d78657a3dfbb95
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313137B1

연결된 노트

불러오는 중…