Sodium Hydroxide → 5-Methoxy-6-(trifluoromethyl)indoline
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[C:12]([F:15])([F:14])[F:13])[NH:8][CH:7]=[CH:6]2.C([BH3-])#N.[Na+].[OH-].[Na+]>C(O)(=O)C.O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[C:12]([F:15])([F:13])[F:14])[NH:8][CH2:7][CH2:6]2참가 물질
6
실험 절차
5 The indole (D8) (67.63 g, 0.315 mol) in glacial acetic acid (500 ml) was treated with sodium cyanoborohydride (40 g, 0.637 mol) at room temperature with stirring. After 3 h at room temperature the reaction mixture was diluted with water (500 ml) and basified with 40% aqueous NaOH with cooling. The mixture was then extracted with dichloromethane (3×500 ml) and the combined extracts were dried (Na2SO4) and evaporated to give the title compound (67.73 g, 99%) as an off-white solid.
후처리
- temperaturewith cooling
- extractionThe mixture was then extracted with dichloromethane (3×500 ml)
- dry with materialthe combined extracts were dried (Na2SO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-359c6b5f5b7c4063a34ec072aca6c3cf
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06313145B1
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