Hydrochloric Acid → 2,3-Difluoro-6-methoxyphenol
반응식
[F:1][C:2]1[CH:3]=[C:4]([O:9][CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C[O:12]B(OC)OC.Cl.OO>CCCCCC>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([O:9][CH3:10])[C:3]=1[OH:12]참가 물질
6
실험 절차
Using the procedure of Example 39, 125 g of 3,4-difluoroanisole (commercial) and 500 ml of a 1.6 M solution of N-butyl-lithium in hexane were reacted at −72° C., and then 92.4 ml of trimethylborate, 500 ml of hydrochloric acid and 120 g of intermediate compound were reacted and the product was reacted with 440 ml of 30% hydrogen peroxide to obtain 82.4 g of the expected product melting at 46.6° C.
후처리
- customwere reacted at −72° C.
출처 및 근거
- ORD 기록
- ord-10cec2e76eb542e8969dfa7c2bbe5564
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06313305B1
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