Hydrochloric Acid → 2,3-Difluoro-6-methoxyphenol

HRID 428837

반응식

HRID 428837 반응식
[F:1][C:2]1[CH:3]=[C:4]([O:9][CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C[O:12]B(OC)OC.Cl.OO>CCCCCC>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([O:9][CH3:10])[C:3]=1[OH:12]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 8470Trimethyl borateHCID 5682503,4-Difluoroanisole

생성물 1

HCID 32697282,3-Difluoro-6-methoxyphenol

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Using the procedure of Example 39, 125 g of 3,4-difluoroanisole (commercial) and 500 ml of a 1.6 M solution of N-butyl-lithium in hexane were reacted at −72° C., and then 92.4 ml of trimethylborate, 500 ml of hydrochloric acid and 120 g of intermediate compound were reacted and the product was reacted with 440 ml of 30% hydrogen peroxide to obtain 82.4 g of the expected product melting at 46.6° C.

후처리

  1. customwere reacted at −72° C.

출처 및 근거

ORD 기록
ord-10cec2e76eb542e8969dfa7c2bbe5564
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313305B1

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