tert-Butyl methyl ether → HCID 178435105, 화합물
반응식
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH3:7].[Br:8]CC([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)=O.C[O:18][C:19](C)(C)[CH3:20]>C(O)C>[Br-:8].[SH:13]1([C:19](=[O:18])[CH2:20][N+:3]2[C:2]([CH3:1])=[C:6]([CH3:7])[S:5][CH:4]=2)[CH:12]=[CH:16][CH:15]=[CH:14]1참가 물질
5
실험 절차
A solution of 4,5-dimethylthiazole (2,2 g, 19.4 mmol) and 2-bromoacetylthiophene (4 g, 19.4 mmol) in ethyl alcohol (20 mL) was refluxed for 3 hours. It was cooled to room temperature and t-butyl methyl ether (10 mL) was added. The reaction mixture was left at room temperature overnight with stirring. The white product separated and was filtered and dried. It was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.
후처리
- customThe white product separated
- filtrationwas filtered
- customdried
- customIt was crystallized from ethyl alcohol (4.42 g, 73%), m.p. 203-205° C.
출처 및 근거
- ORD 기록
- ord-07544ed515c34ce68a593ce274f675ff
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06319934B1
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