Pyridine → 1-(2,3-Dihydrobenzofuran-5-yl)propan-2-one
반응식
[CH3:1][C:2](=C)[CH2:3][C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH2:10][CH2:9][C:8]=2[CH:12]=1.N1C=CC=CC=1.[O:20]=[O+][O-].NC(N)=S>C(Cl)Cl.CO>[O:11]1[C:7]2[CH:6]=[CH:5][C:4]([CH2:3][C:2](=[O:20])[CH3:1])=[CH:12][C:8]=2[CH2:9][CH2:10]1참가 물질
7
실험 절차
A solution of 5-(2-methylallyl)-2,3-dihydrobenzofuran (58 grams, 0.333 mole) and pyridine (27 ml) in methylene chloride (450 ml) and methanol (150 ml) was cooled in a dry ice/acetone bath and a stream of ozone passed through for 1.0 hour. Thiourea (18 grams, 0.24 mole) was added and the mixture was warmed to room temperature. The resultant precipitate was filtered and the mother liquor evaporated to give an oil which was distilled under reduced pressure to give 1-(2,3-dihydrobenzofuran-5-yl)propan-2-one (32 grams, 54%), bp. 110° C. @ 120 mT.
후처리
- custompassed through for 1.0 hour
- filtrationThe resultant precipitate was filtered
- customthe mother liquor evaporated
- customto give an oil which
- distillationwas distilled under reduced pressure
출처 및 근거
- ORD 기록
- ord-bd0ba028d81047af97497267bc46110a
- 출처 데이터셋
- uspto-grants-2001_11
- 특허 번호
- US06319920B1
반응 노트
불러오는 중…