Hydrochloric Acid → HCID 86652654, 화합물

HRID 43026

반응식

HRID 43026 반응식
[F:1][C:2]([F:28])([F:27])[C:3]([NH:5][CH:6]1[C:14]2[C:9](=[CH:10][C:11]([CH2:15][N:16]3[CH:20]=[C:19]([CH2:21][OH:22])[C:18]([C:23]([F:26])([F:25])[F:24])=[N:17]3)=[CH:12][CH:13]=2)[CH2:8][CH2:7]1)=O.B#B.Cl>C1COCC1>[F:28][C:2]([F:1])([F:27])[CH2:3][NH:5][CH:6]1[C:14]2[C:9](=[CH:10][C:11]([CH2:15][N:16]3[CH:20]=[C:19]([CH2:21][OH:22])[C:18]([C:23]([F:24])([F:25])[F:26])=[N:17]3)=[CH:12][CH:13]=2)[CH2:8][CH2:7]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6328200DiboronHCID 445557322,2,2-Trifluoro-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)acetamide

생성물 1

HCID 86652654HCID 86652654, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2,2,2-trifluoro-N-(5-((4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)-2,3-dihydro-1H-inden-1-yl)acetamide (0.172 mmol, 70 mg) in THF (2 mL) was added diborane (1.719 mmol, 1.719 mL) and the whole heated to reflux for 6 h. The reaction mixture was allowed to cool to room temperature before being treated with 2N HCl (3 mL) and left to stand overnight. After this time the crude mixture was applied to an SCX column & eluted with 2N NH3/MeOH. After evaporation, the residue was further purified by prep LCMS to give a clear film (11 mg, 0.028 mmol, 16.3%). MS (ESI): m/z [M+H]+ 394.1.

후처리

  1. temperaturethe whole heated
  2. temperatureto reflux for 6 h
  3. waitleft
  4. washeluted with 2N NH3/MeOH
  5. customAfter evaporation
  6. customthe residue was further purified by prep LCMS
  7. customto give a clear film (11 mg, 0.028 mmol, 16.3%)

출처 및 근거

ORD 기록
ord-f7027af75a864385b6ed2b3a6210bce6
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536214B2

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