p-Toluenesulfonic acid → 1-Pyrrolidino-1-cyclohexene

HRID 430633

반응식

HRID 430633 반응식
[C:1]1(C)[CH:6]=[CH:5][C:4](S(O)(=O)=O)=[CH:3][CH:2]=1.C1(=O)CCCCC1.[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>C1C=CC=CC=1>[C:1]1([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 7967CyclohexanoneHCID 31268Pyrrolidine

생성물 1

HCID 707681-Pyrrolidino-1-cyclohexene

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

1 g of para-toluenesulphonic acid is added to a mixture of 20 mmol of cyclohexanone and 22 mmol of pyrrolidine in 200 ml of dry benzene. The reaction mixture is stirred at reflux until, in the infra-red, the ketone has disappeared, with the enamine concomitantly appearing. The solvent is then evaporated off and the crude residue is purified by distillation in vacuo.

후처리

  1. customThe solvent is then evaporated off
  2. distillationthe crude residue is purified by distillation in vacuo

출처 및 근거

ORD 기록
ord-cdac14b14a784ab9adc38381ddf9d823
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323220B1

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