6-Aminonicotinic acid → (6-Aminopyridin-3-yl)(4-methylpiperazin-1-yl)methanone

HRID 43064

반응식

HRID 43064 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)=[O:8])=[CH:9][CH:10]=1

참가 물질

3

반응물 2

HCID 184966-Aminonicotinic acidHCID 531671-Methylpiperazine

생성물 1

HCID 57781845(6-Aminopyridin-3-yl)(4-methylpiperazin-1-yl)methanone

반응 조건

온도
0 °C

실험 절차

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 6-amino-nicotinic acid and 1-methylpiperazine. The reaction mixture was stirred overnight at 0° C. DCM was used for dilution and extraction instead of EtOAc. The dried organic phase was concentrated to afford an impure sample of the title compound which was used without further purification.

후처리

  1. customThe title compound was prepared in analogy to the procedure
  2. extractionDCM was used for dilution and extraction instead of EtOAc
  3. concentrationThe dried organic phase was concentrated

출처 및 근거

ORD 기록
ord-65aef1e3c6b14e0c923194c276e06732
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536175B2

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