Hydrochloric Acid → Ethyl 2-oxo-3-phenylpropanoate

HRID 430641노트

반응식

HRID 430641 반응식
[C:1]([O:8][CH2:9][CH3:10])(=[O:7])[C:2]([O:4]CC)=O.[CH2:11]([Mg]Cl)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.Cl>C(OCC)C>[O:4]=[C:2]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:1]([O:8][CH2:9][CH3:10])=[O:7]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 7268Diethyl OxalateHCID 178418336HCID 178418336, 화합물

생성물 1

HCID 12292599Ethyl 2-oxo-3-phenylpropanoate수율 98%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

반응 조건

온도
-60 °C

실험 절차

A solution of diethyl oxalate (11.15 mL, 82.1 mmol) in diethyl ether (50 mL) at −78° C. was treated dropwise with 1 M benzylmagnesium chloride in diethyl ether (82 mL, 82 mmol) while maintaining an internal temperature of −60° C. The mixture was stirred for 30 minutes and poured into a mixture of concentrated HCl (8 mL), ice (40 mL), and diethyl ether (50 mL). The organic phase was washed with water and brine, dried (MgSO4), filtered, and concentrated to provide 15.5 g (98%) of the desired product of sufficient purity for subsequent use.

후처리

  1. washThe organic phase was washed with water and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-cdaa373e3812485f97b896f848dab473
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323228B1

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