Hydrochloric Acid → HCID 4738324, 화합물

HRID 430767노트

반응식

HRID 430767 반응식
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH:9]=[C:8]([CH2:12][C:13]([O:15]C)=[O:14])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[OH-].[Na+].Cl.O>CO>[CH3:1][O:2][C:3]1[C:11]2[O:10][CH:9]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[C:7]=2[CH:6]=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 11435946Methyl 2-(7-methoxybenzofuran-3-yl)acetate

생성물 1

HCID 4738324HCID 4738324, 화합물수율 91%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl (7-methoxy-benzofuran-3-yl)acetate (1.12 g) was dissolved in methanol (20 ml). To this solution, 2N aqueous sodium hydroxide solution (5 ml) was added and the resulting solution was stirred at room temperature for 13.5 hours. To this solution, 1N hydrochloric acid (12 ml) was added and the reaction solution was poured into water layer (200 ml), followed by extraction twice with ethyl acetate (50 ml). The organic layers were combined and washed with saturated brine, followed by drying over sodium sulfate. Sodium sulfate was removed by filtration and the solvent was removed under reduced pressure. The residue was recrystallized from hexane/chloroform to obtain the desired compound (0.95 g, yield: 91%).

후처리

  1. extractionfollowed by extraction twice with ethyl acetate (50 ml)
  2. washwashed with saturated brine
  3. dry with materialby drying over sodium sulfate
  4. customSodium sulfate was removed by filtration
  5. customthe solvent was removed under reduced pressure
  6. customThe residue was recrystallized from hexane/chloroform

출처 및 근거

ORD 기록
ord-3c297ee405ad4169931342fe959e72b3
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06323235B1

반응 노트

불러오는 중…