Hydrochloric Acid → HCID 12857528, 화합물

HRID 430899노트

반응식

HRID 430899 반응식
[OH-].[Na+].[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][OH:10].[CH2:11]([O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22])[CH:12]1[O:14][CH2:13]1.Cl>>[CH3:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:13][CH:12]([OH:14])[CH2:11][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH3:22]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 8134Diethylene Glycol Monomethyl EtherHCID 14798Sodium HydroxideHCID 104422242-(2-methoxyethoxy)ethyl glycidyl ether

생성물 1

HCID 12857528HCID 12857528, 화합물수율 75%

반응 조건

온도
70 °C

실험 절차

44.0 g (1.1 mol) of NaOH pellets were added to 360 g (3.0 mol) of diethyleneglycol monomethyl ether, and 176 g (1.0 mol) of 2-(2-methoxyethoxy)ethyl glycidyl ether was gradually dropwise added while stirring at 70° C. After the completion of dropwise addition, the mixture was stirred for about one hour and then stood for cooling at room temperature. Then, the mixture was neutralized with hydrochloric acid, a precipitated salt was filtered off and the liquid was condensed. The liquid was purified by vacuum distillation to give 222 g of 1,3-bis[2-(2-methoxyethoxy)ethoxy]-2-propanol (yield: 75%). The distillation temperature was from 171 to 175° C./0.8 mmHg.

후처리

  1. additionwas gradually dropwise added
  2. additionAfter the completion of dropwise addition
  3. stirringthe mixture was stirred for about one hour
  4. temperaturefor cooling at room temperature
  5. filtrationa precipitated salt was filtered off
  6. customcondensed
  7. distillationThe liquid was purified by vacuum distillation

출처 및 근거

ORD 기록
ord-1408dede6baa48f59d66e4cb6804a746
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06656252B2

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