Hydrogen Bromide → 3-Bromopiperidine-2,6-dione

HRID 430954

반응식

HRID 430954 반응식
[Br:1]Br.[C:3]1(=[O:10])[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1.Br>C(Cl)(Cl)Cl>[Br:1][CH:4]1[CH2:5][CH2:6][C:7](=[O:9])[NH:8][C:3]1=[O:10]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 70726Glutarimide

생성물 1

HCID 125707753-Bromopiperidine-2,6-dione

시약·촉매·용매 1

HCID 6212Chloroform용매

반응 조건

온도
110 °C

실험 절차

4.5 ml bromine were added to 10.2 g glutarimide suspended in 20 ml chloroform and the mixture was stirred in a closed vessel for 90 minutes at a bath temperature of 110° C. After cooling, the vessel was opened and stirring was continued until no more hydrogen bromide escaped. The reaction mixture was evaporated in vacuo, the residue dissolved in ethanol and evaporated again. 17.1 g (99% of theoretical) of the title compound remained in the form of practically white crystals, which melted at 76 to 83° C.

후처리

  1. temperatureAfter cooling
  2. stirringstirring
  3. customThe reaction mixture was evaporated in vacuo
  4. dissolutionthe residue dissolved in ethanol
  5. customevaporated again

출처 및 근거

ORD 기록
ord-e08265c7b9ea453a829702908d998a35
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06656937B2

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