Ethylenediamine → 2-Piperazinone, 3,3-dimethyl-
반응식
C(O[C:4](=[O:9])[C:5](Br)([CH3:7])[CH3:6])C.[CH2:10]([NH2:13])[CH2:11][NH2:12].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[CH3:7][C:5]1([CH3:6])[NH:13][CH2:10][CH2:11][NH:12][C:4]1=[O:9]참가 물질
5
반응 조건
- 온도
- 115 °C
실험 절차
A solution of ethyl-2-bromoisobutyrate (24 mL, 161 mmol) in toluene (150 mL) was added to a mixture of ethylene diamine (70 mL, 1046 mmol, 6.5 equiv) and potassium carbonate (24.4 g, 177 mmol, 1.1 equiv) in toluene (150 mL). The reaction mixture was heated for 20 h at 115° C., cooled and filtered. The filtrate was concentrated and the residue triturated in Et2O to afford 14.2 g of the title compound as a yellow solid: ESI-MS: 129.1 [M+H]+.
후처리
- temperaturecooled
- filtrationfiltered
- concentrationThe filtrate was concentrated
- customthe residue triturated in Et2O
출처 및 근거
- ORD 기록
- ord-b6f1359851554a6e8633af1cffc9717a
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08536175B2
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