Hydrochloric Acid → 6-chloronaphthalene-2-sulfonic Acid

HRID 431523

반응식

HRID 431523 반응식
N[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([OH:15])(=[O:14])=[O:13])[CH:6]=[CH:5]2.N([O-])=O.[Na+].[ClH:20]>O.[Cu]Cl>[Cl:20][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([OH:15])(=[O:14])=[O:13])[CH:6]=[CH:5]2

참가 물질

6

반응물 3

HCID 313Hydrochloric Acid2회HCID 71166-Amino-2-naphthalenesulfonic acidHCID 23668193Sodium Nitrite

생성물 1

HCID 100146476-chloronaphthalene-2-sulfonic Acid

시약·촉매·용매 2

HCID 62652Cuprous chloride촉매HCID 962Water용매2회

실험 절차

6-Amino-2-napthalenesulfonic acid (88.0 g, 0.4 mol) was suspended in 5 N HCl (200 mL) and water (150 mL) and cooled to 3° C. A solution of sodium nitrite (27.0 g, 0.4 mol) in water (50 mL) was added dropwise over two hours. After one additional hour, the mixture was poured in several portions into a stirred suspension of copper(I) chloride (39.6 g, 60.6 mmol) in 5 N HCl (200 mL). Considerable foaming occurred during this addition. After standing overnight at room temperature, the mixture was concentrated on a rotary evaporator to a brown solid that was then dried in a vacuum oven overnight at 100° C. to provide the acid (111.9 g)

후처리

  1. additionConsiderable foaming occurred during this addition
  2. concentrationthe mixture was concentrated on a rotary evaporator to a brown solid that
  3. customwas then dried in a vacuum oven overnight at 100° C.

출처 및 근거

ORD 기록
ord-42a1b7d98e294a1e889712365fc93b52
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660739B1

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