Water → 2,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate

HRID 432571노트

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HRID 432571 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:8]=[CH:9][NH:10][CH:11]=2)[CH:2]=1.[OH-].[K+].[C:14]([O:17][CH2:18][C:19]([CH3:23])([CH3:22])[CH2:20]Br)(=[O:16])[CH3:15].O>CS(C)=O.C(Cl)(Cl)Cl>[C:14]([O:17][CH2:18][C:19]([CH3:23])([CH3:22])[CH2:20][N:10]1[CH:11]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[N:8]=[CH:9]1)(=[O:16])[CH3:15]

참가 물질

7

반응물 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 133577153-Bromo-2,2-dimethylpropyl acetateHCID 178420772HCID 178420772, 화합물

생성물 1

HCID 545188152,2-Dimethyl-3-(4-pyridin-3-yl-imidazol-1-yl)-propyl acetate

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 6212Chloroform용매

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온도
70 °C

실험 절차

To a solution of 4-pyridin-3-yl-imidazole (50 mg) in DMSO (1.7 mL) was added powered KOH (57 mg) and 3-bromo-2,2-dimethylpropyl acetate and the resulting suspension was heated at 70° C. for 48 hours. Water was added followed by CHCl3, the aqueous layer was extracted with CHCl3, the combined organic layers were washed with brine, dired over Na2SO4 and evaporated in vacuo. The residue was purified by preparative TLC (10% MeOH-90% CH2Cl2) the title compound as slightly yellow oil.

후처리

  1. extractionthe aqueous layer was extracted with CHCl3
  2. washthe combined organic layers were washed with brine
  3. customevaporated in vacuo
  4. customThe residue was purified by preparative TLC (10% MeOH-90% CH2Cl2) the title compound as slightly yellow oil

출처 및 근거

ORD 기록
ord-acb142e284154a0bbf859dcb7908e8a6
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664238B1

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