Acetic Acid → 1-(5-Chloro-pyridin-2-yl)-1H-imidazole-4-carboxylic Acid Ethyl Ester
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=1.[CH:9]([O:16][CH2:17][CH3:18])([O:13]CC)OCC.[N+:19]([CH2:22][C:23](OCC)=O)([O-])=O.[C:28](O)(=O)C>[Fe]>[CH2:17]([O:16][C:9]([C:22]1[N:19]=[CH:28][N:1]([C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][N:3]=2)[CH:23]=1)=[O:13])[CH3:18]참가 물질
6
실험 절차
Following the general method described in example 384, 2-amino-5-chloropyridine was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid. After workup and chromatography the title compound was obtained as a beige crystalline solid. Mp. 163-164° C. (AcOEt), MS: m/e=252 (M+H+).
출처 및 근거
- ORD 기록
- ord-d6f0f3bc6ffc4872a3395895ca6eea0e
- 출처 데이터셋
- uspto-grants-2003_12
- 특허 번호
- US06667335B2
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