Hydrochloric Acid → 3-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

HRID 434029

반응식

HRID 434029 반응식
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])=[N:7][O:8][C:9]=1[CH3:10])=[O:4].CO.[OH-].[Na+].Cl>O>[C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])=[N:7][O:8][C:9]=1[CH3:10])([OH:4])=[O:2]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 18756272Methyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate

생성물 1

HCID 64841013-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid수율 96.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 4-methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole (2.20 g, 8.84 mmol), MeOH (25 ml), and 2N NaOH (8.8 ml) was heated at 50° C. overnight (19 h). The reaction was cooled to room temperature, diluted with H2O, and acidified (2N HCl) to less than pH 3. The mixture was extracted with EtOAc (twice) and the combined extracts were washed (brine), dried (MgSO4), filtered, and concentrated to give the title compound (1.88 g, 96%). This material was used without further purification.

후처리

  1. extractionThe mixture was extracted with EtOAc (twice) and the combined extracts
  2. washwere washed (brine)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-e39a911cdc174001b9a03a0ff5720557
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06670373B1

연결된 노트

불러오는 중…