Hydrochloric Acid → [1-((S)-2-amino-3-hydroxy-propyl)-piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride

HRID 434300

반응식

HRID 434300 반응식
C(OC([N:8]1[C@@H:12]([CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[CH2:16][CH2:15]2)[CH2:11][O:10]C1(C)C)=O)(C)(C)C.Cl>C(O)C>[ClH:27].[NH2:8][C@H:12]([CH2:11][OH:10])[CH2:13][N:14]1[CH2:15][CH2:16][CH:17]([C:20]([C:21]2[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=2)=[O:28])[CH2:18][CH2:19]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68809159(S)-4-[4-(4-chloro-benzoyl)-piperidin-1-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

생성물 1

HCID 68809448[1-((S)-2-amino-3-hydroxy-propyl)-piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

(S)-4-[4-(4-chloro-benzoyl)-piperidin-1-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (0.68 g, 1.55 mmol) is added to a solution of hydrogen chloride in ethanol (5 ml, 5.5M). The reaction mixture is stirred at ambient temperature for 1 hour, then evaporated to dryness to afford [1-((S)-2-amino-3-hydroxy-propyl)-piperidin-4-yl]-(4-chloro-phenyl)-methanone hydrochloride. [MH] 297.0.

후처리

  1. customevaporated to dryness

출처 및 근거

ORD 기록
ord-713c0094f74b43459937b20cdfdf2805
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06670379B2

연결된 노트

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