Acetyl chloride → 2-Acetoxy-1-(4-acetylphenyl)propane

HRID 434372

반응식

HRID 434372 반응식
[C:1]([O:4][CH:5]([CH3:13])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:3])[CH3:2].[Cl-].[Al+3].[Cl-].[Cl-].[C:18](Cl)(=[O:20])[CH3:19]>ClC(Cl)C>[C:1]([O:4][CH:5]([CH3:13])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:18](=[O:20])[CH3:19])=[CH:9][CH:8]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6367Acetyl chloride2회HCID 16457Benzeneethanol, alpha-methyl-, 1-acetateHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 204938272-Acetoxy-1-(4-acetylphenyl)propane

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

2-Acetoxy-1-phenylpropane (5.2 g) in acetyl chloride (20 ml) was added dropwise to a stirred solution of aluminium chloride (16.0 g) and acetyl chloride (4.2 ml) in dichloroethane (150 ml). The mixture was stirred at ambient temperature for 72 hours, poured on to ice (500 g) and the organic phase was separated. The organic phase and washings were washed with sodium bicarbonate solution, dried (MgSO4) and evaporated to an oil. Chromatography of the oil on alumina, eluting with ether/petrol gave the title compound (4.5 g).

후처리

  1. customthe organic phase was separated
  2. washThe organic phase and washings were washed with sodium bicarbonate solution
  3. dry with materialdried (MgSO4)
  4. customevaporated to an oil
  5. washChromatography of the oil on alumina, eluting with ether/petrol

출처 및 근거

ORD 기록
ord-85d020a631a04043ac5817163c8fe86a
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04396627

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