Hydrochloric Acid → HCID 178418513, 화합물

HRID 4349

반응식

HRID 4349 반응식
Br.Br[CH2:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=1)=O.[S-:12][C:13]#[N:14].[K+].Cl.[OH2:17]>C(O)C>[OH:17][C:13]1[S:12][CH:3]=[C:4]([C:6]2[CH:11]=[CH:10][N:9]=[CH:8][CH:7]=2)[N:14]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 516872Potassium thiocyanateHCID 27762394-(Bromoacetyl)pyridine hydrobromide

생성물 1

HCID 178418513HCID 178418513, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of α-bromo-4-acetylpyridine hydrobromide (140.0 g, 0.50 mol) and potassium thiocyanate (53.4 g, 0.55 mol) in absolute ethanol (1500 mL) was heated to reflux for two hours. To the resulting mixture was added concentrated hydrochloric acid (250 mL) and water (500 mL) and reflux continued for five hours. After cooling, the crystallized solid was collected by filtration and washed with ethanol. The resulting material was suspended in water and neutralized with aqueous sodium bicarbonate to obtain, after filtration and drying, 2-hydroxy-4-(4-pyridyl)thiazole 39.0 g, 44%). mp. 250° C.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for two hours
  3. temperaturereflux
  4. temperatureAfter cooling
  5. filtrationthe crystallized solid was collected by filtration
  6. washwashed with ethanol
  7. customto obtain
  8. filtrationafter filtration
  9. customdrying

출처 및 근거

ORD 기록
ord-765591272e9a4caba598731704b65f44
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725606

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