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Hydrochloric Acid → HCID 53844359, 화합물

HRID 435257
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HRID 435257 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:8]([OH:10])=[O:9])[N:6]=1.[C:19](OC(=O)C)(=[O:21])C.C(=O)(O)[O-].[Na+].Cl>C(O)=O>[CH:19]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:8]([OH:10])=[O:9])[N:6]=1)=[O:21]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 516892Sodium BicarbonateHCID 545075972-(2-Aminothiazol-4-yl)-2-cyclohexyloxyiminoacetic acid

생성물 1

HCID 53844359HCID 53844359, 화합물수율 60.4%

시약·촉매·용매 1

HCID 284Formic Acid
용매

실험 절차

2-(2-Aminothiazol-4-yl)-2-cyclohexyloxyiminoacetic acid (syn isomer, 1.5 g.), acetic anhydride (2.27 g.) and formic acid (1.03 g.) were treated in a similar manner to that of Example F-(5), and the oil obtained was suspended in an aqueous solution of sodium bicarbonate. The suspension was adjusted to pH 3.5 with 10% hydrochloric acid. The precipitates were collected by filtration, washed with water and dried to give 2-(2-formamidothiazol-4-yl)-2-cyclohexyloxyiminoacetic acid (syn isomer, 1.0 g.), mp. above 230° C.

후처리

  1. customthe oil obtained
  2. filtrationThe precipitates were collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-15a8c4338b3144cfa867d5a7e7dbd774
출처 데이터셋
uspto-grants-1983_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04400379

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