Salicylaldehyde → 2-Phenylglycine

HRID 435464

반응식

HRID 435464 반응식
[CH:1]1[CH:6]=[CH:5][C:4]([C@H:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1.C(=O)[C:13]1[C:14](=[CH:16][CH:17]=[CH:18][CH:19]=1)[OH:15]>C(O)(=O)C>[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:6]=1.[CH:17]1[C:18]([CH:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:19][CH:13]=[C:14]([OH:15])[CH:16]=1

참가 물질

5

반응물 2

HCID 6998SalicylaldehydeHCID 99291L-Phenylglycine

생성물 2

HCID 38662-PhenylglycineHCID 921434-Hydroxyphenylglycine

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

6 g of L-phenylglycine or L-p-hydroxyphenylglycine were suspended in a mixture of 20 ml of 95% acetic acid and 0.2 ml (0.05 mole per mole of the L-amino acid used) of salicylaldehyde. The suspension was stirred at 100° C. for 2 hours. After the reaction, the mixture was cooled to room temperature, and the crystalline precipitates were collected by filtration and then washed with methanol. DL-phenylglycine or DL-p-hydroxyphenylglycine was thereby obtained. The results are shown in Table 17.

후처리

  1. customAfter the reaction
  2. temperaturethe mixture was cooled to room temperature
  3. customthe crystalline precipitates
  4. filtrationwere collected by filtration
  5. washwashed with methanol

출처 및 근거

ORD 기록
ord-f17dfdb554054d039e49e8fe4c287923
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04401820

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