Salicylaldehyde → 2-Phenylglycine

반응식

[CH:1]1[CH:6]=[CH:5][C:4]([C@H:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1.C(=O)[C:13]1[C:14](=[CH:16][CH:17]=[CH:18][CH:19]=1)[OH:15]>C(O)(=O)C>[CH:1]1[CH:2]=[CH:3][C:4]([CH:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:6]=1.[CH:17]1[C:18]([CH:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:19][CH:13]=[C:14]([OH:15])[CH:16]=1

참가 물질

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온도: 100 °C

실험 절차

6 g of L-phenylglycine or L-p-hydroxyphenylglycine were suspended in a mixture of 20 ml of 95% acetic acid and 0.2 ml (0.05 mole per mole of the L-amino acid used) of salicylaldehyde. The suspension was stirred at 100° C. for 2 hours. After the reaction, the mixture was cooled to room temperature, and the crystalline precipitates were collected by filtration and then washed with methanol. DL-phenylglycine or DL-p-hydroxyphenylglycine was thereby obtained. The results are shown in Table 17.