Hydrochloric Acid → 10-Chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin

HRID 435649노트

반응식

HRID 435649 반응식
[ClH:1].[CH3:2][N:3]([CH3:23])[S:4]([C:7]1[CH:22]=[CH:21][C:10]2[S:11][C:12]3[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=3[CH:14](O)[CH2:15][C:9]=2[CH:8]=1)(=[O:6])=[O:5].[Cl-].[Ca+2].[Cl-]>C1C=CC=CC=1>[Cl:1][CH:14]1[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[S:11][C:10]2[CH:21]=[CH:22][C:7]([S:4](=[O:6])(=[O:5])[N:3]([CH3:23])[CH3:2])=[CH:8][C:9]=2[CH2:15]1

참가 물질

5

반응물 3

HCID 313Hydrochloric Acid2회HCID 5284359Calcium ChlorideHCID 12223972HCID 12223972, 화합물

생성물 1

HCID 1561900510-Chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

Hydrochloric acid gas is introduced at 10° C for 2 hours into a mixture of 12 g of 10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin-10-ol, 250 ml of benzene and 20 g of calcium chloride. The mixture is then left to stand at room temperature for 20 hours. The excess hydrochloric acid is driven off by the introduction of nitrogen. The mixture is filtered and evaporated under reduced pressure. 10-chloro-10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]thiepin is obtained.

후처리

  1. waitThe mixture is then left
  2. filtrationThe mixture is filtered
  3. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-cca5d19679774d61aaa2a9be6f55b303
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006145

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