Hydrochloric Acid → N-(2-methyl-4-nitrophenyl)ethane-1,2-diamine hydrochloride

HRID 436333

반응식

HRID 436333 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH3:11].O.[CH2:13]([NH2:16])[CH2:14][NH2:15].C(N)CN.Cl>>[ClH:1].[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:15][CH2:14][CH2:13][NH2:16])=[C:3]([CH3:11])[CH:4]=1)([O-:10])=[O:9]

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 3301EthylenediamineHCID 83315Benzene, 1-chloro-2-methyl-4-nitro-HCID 12200817Ethylenediamine monohydrate

생성물 1

HCID 17336835N-(2-methyl-4-nitrophenyl)ethane-1,2-diamine hydrochloride수율 87%

실험 절차

51.45 g (0.3 mole) of 2-chloro-5-nitro-toluene is added to 200 cm3 (2.5 moles) ethylenediamine hydrate. The mixture is heated at reflux for 5 hours, and the excess of ethylene diamine is then eliminated under vacuum. The residue is treated with 300 cm3 of a 5N solution of hydrochloric acid, Drying yields 60.5 g of 4-nitro-2-methyl-N-(β-aminoethyl)aniline monohydrochloride, which is washed with acetone.

후처리

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 5 hours
  3. customDrying

출처 및 근거

ORD 기록
ord-c66817897ba640ffb112ae0d14cd0f16
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04008272

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