Hydrochloric Acid → 1-Hydrazinyl-3,4-dihydroisoquinoline

HRID 436430

반응식

HRID 436430 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][N:3]=1.Cl.C(OC1C2C(=CC=CC=2)CC[N:17]=1)C.[Cl-].[NH4+].C(=O)([O-])[O-].[Na+].[Na+].NN>C(O)C>[NH:1]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][N:3]=1)[NH2:17]

참가 물질

8

반응물 6

HCID 313Hydrochloric AcidHCID 9321HydrazineHCID 10340Sodium CarbonateHCID 25517Ammonium ChlorideHCID 97938243,4-Dihydro-isoquinolin-1-ylamineHCID 123490381-Ethoxy-3,4-dihydroisoquinoline

생성물 1

HCID 123490411-Hydrazinyl-3,4-dihydroisoquinoline

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
25 °C

실험 절차

A mixture of 1-amino-3,4-dihydroisoquinoline (VI: R=R'=Y=Y'=Z=Z'=H) hydrochloride (m.p. 133°-134° C., 0.5 g.), prepared from 1-ethoxy-3,4-dihydroisoquinoline and ammonium chloride, sodium carbonate (0.38 g.), hydrazine (0.41 g.) and ethanol (15 ml.) was stirred (at 25° C.). The mixture was filtered. An ether solution of the crystals which separated from the filtrate on chilling was washed with water, dried and filtered. Concentration of the filtrate and crystallization of the residue from ether afforded 1-hydrazino-3,4-dihydroisoquinoline (0.44 g.).

후처리

  1. filtrationThe mixture was filtered
  2. customAn ether solution of the crystals which separated from the filtrate
  3. temperatureon chilling
  4. washwas washed with water
  5. customdried
  6. filtrationfiltered
  7. customConcentration of the filtrate and crystallization of the residue from ether

출처 및 근거

ORD 기록
ord-c56f3b2b50184e3084ea8ec85fc05f53
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04009170

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