Hydrochloric Acid → 2-Phenyl-3-(3-pyrrolidinopropionyl)benzofuran

HRID 436497노트

반응식

HRID 436497 반응식
[C:1]1([C:7]2[O:8][C:9]3[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=3[C:11]=2[C:12](=[O:14])[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:19]=O.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1.Cl>C(O)(C)C.C(O)C>[C:1]1([C:7]2[O:8][C:9]3[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=3[C:11]=2[C:12](=[O:14])[CH2:13][CH2:19][N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 31268PyrrolidineHCID 130247261-(2-Phenylbenzofuran-3-yl)ethanone

생성물 1

HCID 214527512-Phenyl-3-(3-pyrrolidinopropionyl)benzofuran

시약·촉매·용매 2

HCID 702Ethanol용매HCID 3776Isopropanol용매

실험 절차

To a solution of 23.6 grams of 2-phenyl-3-acetylbenzofuran in 70 milliliters of isopropanol was added 4.2 grams of paraformaldehyde, 10 grams of pyrrolidine and 30 milliliters of a saturated solution of hydrogen chloride in ethanol and the mixture was heated under reflux at its boiling point for 10 hours.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux at its boiling point for 10 hours

출처 및 근거

ORD 기록
ord-fceb410546054e4badc44089db582370
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04009184

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