Sodium Hydroxide → N-[[(4-carboxyphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine

HRID 4366노트

반응식

HRID 4366 반응식
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH:14][N:15]2[CH2:20][CH:19]=[CH:18][CH2:17][CH2:16]2)=[O:13])=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO.C(Cl)(Cl)Cl>[C:3]([C:5]1[CH:6]=[CH:7][C:8]([NH:11][C:12]([NH:14][N:15]2[CH2:16][CH:17]=[CH:18][CH2:19][CH2:20]2)=[O:13])=[CH:9][CH:10]=1)([OH:4])=[O:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 13534723N-[[(4-methoxycarbonylphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine

생성물 1

HCID 13534725N-[[(4-carboxyphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine수율 56.6%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6212Chloroform용매

실험 절차

To a solution of N-[[(4-methoxycarbonylphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine (1.21 g) in a mixture of methanol (30 ml) and chloroform (30 ml) was added. 1N sodium hydroxide (10 ml) and the mixture was stirred at ambient temperature for 18 hours. After evaporation of the solvent, the residue was extracted with chloroform (20 ml×3). The extract was washed with water, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by column chromatography on silica gel (40 g) eluting with chloroform, to give N-[[(4-carboxyphenyl)-carbamoyl]amino]-1,2,3,6-tetrahydropyridine (0.65 g).

후처리

  1. additionwas added
  2. customAfter evaporation of the solvent
  3. extractionthe residue was extracted with chloroform (20 ml×3)
  4. washThe extract was washed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified by column chromatography on silica gel (40 g)
  8. washeluting with chloroform

출처 및 근거

ORD 기록
ord-824d03c3210447cc84bae0d08c4e9730
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725608

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