Isophorone → 4-Bromo-3,5,5-trimethylcyclohex-2-en-1-one

HRID 436977노트

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HRID 436977 반응식
[O:1]=[C:2]1[CH2:9][C:6]([CH3:8])([CH3:7])[CH2:5][C:4]([CH3:10])=[CH:3]1.[Br:11]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[CH3:10][C:4]1[CH:5]([Br:11])[C:6]([CH3:8])([CH3:7])[CH2:9][C:2](=[O:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 6544IsophoroneHCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimide

생성물 1

HCID 127940644-Bromo-3,5,5-trimethylcyclohex-2-en-1-one

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A mixture of isophorone (13.82 g; 0.1 Mole) and N-bromo-succinimide (17.80 g; 0.1 Mole) in the presence of traces of α,α'-azodiisobutyronitrile was refluxed in 500 ml of CCl4 during 15 minutes. 500 ml of petrol-ether (30°-50° C.) were then added to the cool reaction mixture and the succinimide thus precipitated was filtered off. By evaporating the volatile component of the clear filtrate, crude 3,5,5-trimethyl-4-bromo-cyclohex-2-en-1-one was obtained.

후처리

  1. customthe succinimide thus precipitated
  2. filtrationwas filtered off
  3. customBy evaporating the volatile component of the clear filtrate

출처 및 근거

ORD 기록
ord-d57c7bd0ac664381a268555b0932140c
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04029107

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