2,5-Dichlorobenzoic acid → 5-Chloro-2-[2-methyl-3-(trifluoromethyl)anilino]benzoic acid

HRID 437198

반응식

HRID 437198 반응식
Cl[C:2]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C(O)CCCC.[OH-].[Na+].[CH3:20][C:21]1[C:27]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:25]=[CH:24][C:22]=1[NH2:23]>[Cu]>[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([OH:6])=[O:5])[C:2]([NH:23][C:22]2[CH:24]=[CH:25][CH:26]=[C:27]([C:28]([F:29])([F:30])[F:31])[C:21]=2[CH3:20])=[CH:10][CH:9]=1

참가 물질

6

반응물 4

HCID 57842,5-Dichlorobenzoic acidHCID 62761-PentanolHCID 14798Sodium HydroxideHCID 2735932Trifluoromethyl toluidine

생성물 1

HCID 451177035-Chloro-2-[2-methyl-3-(trifluoromethyl)anilino]benzoic acid

시약·촉매·용매 1

HCID 23978Copper촉매

실험 절차

To a solution of 25 g. of 2,5-dichlorobenzoic acid in 125 ml. of n-pentyl alcohol add 4.8 g. of sodium hydroxide pellets, 25 g. of 2-methyl-3-trifluoromethylaniline and 2 g. of copper powder. With constant stirring, reflux the reaction mixture for 18 hours. Concentrate the mixture to one half volume and dilute with water and ether. Acidify the aqueous layer to yield the product which is recrystallized from methanol, m.p. 220°-222° C.

후처리

  1. temperatureWith constant stirring, reflux the reaction mixture for 18 hours
  2. concentrationConcentrate the mixture to one half volume
  3. additiondilute with water and ether
  4. customto yield the product which
  5. customis recrystallized from methanol, m.p. 220°-222° C.

출처 및 근거

ORD 기록
ord-4d4f4c4afad6436984261a6ffd258e11
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04029815

연결된 노트

불러오는 중…