Hydrochloric Acid → HCID 12535843, 화합물

HRID 437443노트

반응식

HRID 437443 반응식
[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([O:19]CC)=[O:18].[OH-].[Na+].Cl>>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([OH:19])=[O:18]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12535800HCID 12535800, 화합물

생성물 1

HCID 12535843HCID 12535843, 화합물수율 100.2%

실험 절차

A solution of ethyl 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carboxylate (2 g., 6.9 mmole) in 1N NaOH (20 ml., 20 mmole) was heated at reflux for 10 minutes. The solution was cooled and acidified with 6N HCl to yield the title product (1.8 g., m.p. 168°-184°). Recrystallization from acetonitrile gave 1.2 g. of colorless crystals, m.p. 186°-188°.

후처리

  1. temperatureat reflux for 10 minutes
  2. temperatureThe solution was cooled

출처 및 근거

ORD 기록
ord-ce4c3b87b1b94626854d964a88691da3
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031093

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