Aziridine → HCID 21428829, 화합물

HRID 437618

반응식

HRID 437618 반응식
[NH:1]1[CH2:3][CH2:2]1.C(=O)([O-])O.[Na+].[OH:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13].[OH-].[Na+]>O.ClC(Cl)Cl>[OH:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([N:1]1[CH2:3][CH2:2]1)=[O:13]

참가 물질

7

반응물 4

HCID 9033AziridineHCID 14798Sodium HydroxideHCID 74041Salicyloyl chlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 21428829HCID 21428829, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6212Chloroform용매

반응 조건

온도
-5 °C

실험 절차

To 690 parts of a solution of aziridine in water 0.875M are added 42 parts of sodium hydrogen carbonate while cooling in an ice-salt bath at -5° C. While stirring vigorously, there is added dropwise, during a 30 minutes period, a solution of 78.8 parts of 2-hydroxybenzoyl chloride in 150 parts of trichloromethane at a temperature below 5° C. The reaction mixture is allowed to reach 25° C while stirring, and a diluted sodium hydroxide solution is added to pH 8. The product is extracted three times with trichloromethane. The combined extracts are washed three times with water, dried, filtered and evaporated, yielding 56 parts of 1-(2-hydroxybenzoyl)aziridine as a residue.

후처리

  1. additionthere is added dropwise, during a 30 minutes period
  2. customat a temperature below 5° C
  3. customto reach 25° C
  4. stirringwhile stirring
  5. extractionThe product is extracted three times with trichloromethane
  6. washThe combined extracts are washed three times with water
  7. customdried
  8. filtrationfiltered
  9. customevaporated

출처 및 근거

ORD 기록
ord-d831ca452c1d40e9aa3a624c99eea2a9
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04031226

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