Methanol → N-(5-carboxy-2,3,4,5-tetrahydroxy-pentyl)-L-(+)-glutamic acid

HRID 438012

반응식

HRID 438012 반응식
O=[CH:2][C@@H:3]([C@H:5]([C@@H:7]([C@@H:9]([C:11]([OH:13])=[O:12])[OH:10])[OH:8])[OH:6])[OH:4].[NH2:14][C@H:15]([C:21]([OH:23])=[O:22])[CH2:16][CH2:17][C:18]([OH:20])=[O:19].CO>[Ni].O>[C:11]([CH:9]([OH:10])[CH:7]([OH:8])[CH:5]([OH:6])[CH:3]([OH:4])[CH2:2][NH:14][C@H:15]([C:21]([OH:23])=[O:22])[CH2:16][CH2:17][C:18]([OH:20])=[O:19])([OH:13])=[O:12]

참가 물질

6

반응물 3

HCID 887MethanolHCID 33032L-Glutamic AcidHCID 65041Glucuronic Acid

생성물 1

HCID 54046356N-(5-carboxy-2,3,4,5-tetrahydroxy-pentyl)-L-(+)-glutamic acid

시약·촉매·용매 2

HCID 935Nickel촉매HCID 962Water용매

실험 절차

As starting material D-glucuronic acid and L-(+)-glutamic acid were used. The reductive amination was carried out using Raney nickel as a catalyst and heating for 2 hours to 50° C. and for 4 hours to 70° C. The product obtained had a melting point of 90° C. (with sintering) an RF -value of 0.70 (determined on DC-finished plates of silica gel G (Merck) with a transporting liquid made up of 70 parts by volume of methanol and 30 parts by volume of water).

후처리

  1. temperatureheating for 2 hours to 50° C. and for 4 hours to 70° C
  2. customThe product obtained

출처 및 근거

ORD 기록
ord-91fdf7bb5232460c8b88feb0fe6abf61
출처 데이터셋
uspto-grants-1977_06
특허 번호
US04032676

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