Hydrochloric Acid → 1-(4-Methoxyphenyl)cyclobutane-1-carboxylic acid

HRID 440532노트

반응식

HRID 440532 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:13]#N)[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[OH-:15].[K+].C(O)COCCO.Cl.[OH2:25]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:13]([OH:25])=[O:15])[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

참가 물질

6

반응물 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 8117Diethylene GlycolHCID 14797Potassium HydroxideHCID 219020981-(4-Methoxyphenyl)cyclobutane-1-carbonitrile

생성물 1

HCID 167699461-(4-Methoxyphenyl)cyclobutane-1-carboxylic acid

실험 절차

A mixture of 1-(4-methoxyphenyl)cyclobutane carbonitrile (41 g), potassium hydroxide (20 g) and diethylene glycol (160 ml) was heated under reflux for 3.5 hours. The mixture was added to water, acidified with dilute hydrochloric acid and extracted with ether. The extract yielded 1-(4-methoxyphenyl)cyclobutane carboxylic acid.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3.5 hours
  3. extractionextracted with ether

출처 및 근거

ORD 기록
ord-b88dba37139741bea049d5b66a6142bf
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05519034

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