Hydrochloric Acid → 2-Methyl-5-(4-chlorobenzylidene)-cyclopentanone

HRID 440568노트

반응식

HRID 440568 반응식
[OH-].[Na+].[Cl:3][C:4]1[CH:21]=[CH:20][C:7]([CH:8]=[C:9]2[CH2:13][CH2:12][C:11](C)([C:14](OC)=O)[C:10]2=[O:19])=[CH:6][CH:5]=1.Cl>O>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([CH:8]=[C:9]2[CH2:13][CH2:12][CH:11]([CH3:14])[C:10]2=[O:19])=[CH:20][CH:21]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67742476Methyl 3-(4-chlorobenzylidene)-1-methyl-2-oxocylopentanecarboxylate

생성물 1

HCID 537529512-Methyl-5-(4-chlorobenzylidene)-cyclopentanone

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

A solution of 12 g of sodium hydroxide in 20 ml of water was added to 10 g of methyl 3-(4-chloro-benzylidene)-1-methyl-2-oxocylopentanecarboxylate (I-1) (prepared in Example 1). The mixture was stirred for 2 hours at 80° C. The reaction mixture was poured into 10% aqueous solution of hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 4.1 g of an oily matter (yield, 51.8%).

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated
  5. customto obtain
  6. custom4.1 g of an oily matter (yield, 51.8%)

출처 및 근거

ORD 기록
ord-23395d6cb26a41428953a5a61b9eee6c
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05519160

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