Triethylamine → 1-{4-[2-(2-Carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline

HRID 441249

반응식

HRID 441249 반응식
[NH2:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[C:20]12[C:27]3=[CH:28][CH:29]=[CH:30][CH:31]=[C:26]3[C:25](=[O:32])[O:24][C:22](=[O:23])[C:21]1=[CH:33][CH:34]=[CH:35][CH:36]=2.C(N(CC)CC)C>CN(C)C1C=CN=CC=1.ClCCl>[C:22]([C:21]1[CH:33]=[CH:34][CH:35]=[CH:36][C:20]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=1[C:25]([NH:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1)=[O:32])([OH:24])=[O:23]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 72794Diphenic anhydrideHCID 2984117(4-aminophenyl)(3,4-dihydroquinolin-1(2H)-yl)methanone

생성물 1

HCID 224051021-{4-[2-(2-Carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline수율 84%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

실험 절차

A mixture of 1-(4-aminobenzoyl)-1,2,3,4-tetrahydroquinoline (252 mg), diphenic anhydride (224 mg), triethylamine (202 mg) and catalytic amount of 4-dimethylaminopyridine in dichloromethane (15 ml) was stirred for 8 hours at ambient temperature. The mixture was evaporated in vacuo and diluted with ethyl acetate and washed with saturated sodium hydrogen carbonate aqueous solution, brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo and triturated from ethyl acetate to give 1-{4-[2-(2-carboxyphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoline (400 mg).

후처리

  1. customThe mixture was evaporated in vacuo
  2. additiondiluted with ethyl acetate
  3. washwashed with saturated sodium hydrogen carbonate aqueous solution, brine
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated in vacuo
  6. customtriturated from ethyl acetate

출처 및 근거

ORD 기록
ord-0cfb53e26d7849009cbdc96b6092b079
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521170

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