Mannitol → Docetaxel Mannitol

반응식

[CH2:1]([OH:12])[C@H:2]([C@H:4]([C@@H:6]([C@@H:8]([CH2:10][OH:11])[OH:9])[OH:7])[OH:5])[OH:3].[CH3:13][C:14]1[C@@H:31]([O:32][C:33]([C@H:35]([OH:51])[C@@H:36]([NH:43][C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)=[O:34])[CH2:30][C@:26]2([OH:52])[C:27]([CH3:29])([CH3:28])[C:15]=1[C@@H:16]([OH:70])[C:17]([C@@:19]1([CH3:69])[C@H:24]([C@@H:25]2[O:53][C:54]([C:56]2[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=2)=[O:55])[C@:23]2([O:64][C:65]([CH3:67])=[O:66])[CH2:62][O:63][C@@H:22]2[CH2:21][C@@H:20]1[OH:68])=[O:18].C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.O>>[CH3:13][C:14]1[C@@H:31]([O:32][C:33]([C@H:35]([OH:51])[C@@H:36]([NH:43][C:44]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:45])[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)=[O:34])[CH2:30][C@:26]2([OH:52])[C:27]([CH3:28])([CH3:29])[C:15]=1[C@@H:16]([OH:70])[C:17]([C@@:19]1([CH3:69])[C@H:24]([C@@H:25]2[O:53][C:54]([C:56]2[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=2)=[O:55])[C@:23]2([O:64][C:65]([CH3:67])=[O:66])[CH2:62][O:63][C@@H:22]2[CH2:21][C@@H:20]1[OH:68])=[O:18].[CH2:10]([OH:11])[C@H:8]([C@H:6]([C@@H:4]([C@@H:2]([CH2:1][OH:12])[OH:3])[OH:5])[OH:7])[OH:9]

참가 물질

반응물 3

HCID 6251Mannitol

HCID 148124Docetaxel

HCID 22814120Glucose Monohydrate

생성물 1

HCID 86641782Docetaxel Mannitol

실험 절차

An aliquot of the mannitol solution was added to the vessel containing the docetaxel solution, which was then re-sealed and mixed until homogeneous (about 15 minutes) at about 600-800 RPM. The mixed solution was then filtered, and a number of pre-sterilized lyophilization vials were aseptically filled with the filtered solution. The vials were immediately transferred to a freeze-dryer and lyophilized under vacuum using nitrogen. A lyophilizate was obtained, and used to reconstitute clear solutions with the sucrose fatty acid ester diluent. The clear solution was further diluted for administrative purposes in saline and D5W. Stability measurements indicated that the solutions remained clear and non-precipitated after 24 hours.