Water → 2-(2-Phenylethyl)oxirane

HRID 442506

반응식

HRID 442506 반응식
[C:1]1([CH2:7][CH2:8][CH:9]=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I-].[CH3:12][S+](C)(C)=O.[H-].[Na+].O>CS(C)=O>[O:10]1[CH:9]([CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12]1

참가 물질

6

반응물 4

HCID 962WaterHCID 7707BenzenepropanalHCID 24758Sodium hydrideHCID 74498Sulfoxonium, trimethyl-, iodide (1:1)

생성물 1

HCID 1359552-(2-Phenylethyl)oxirane

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

3-Phenylpropionaldehyde (26.8 g.) is added under nitrogen to the ylide prepared from trimethylsulfoxonium iodide (48.4 g.) and sodium hydride (55% dispersion in oil; 9.6 g.) in dry dimethylsulfoxide (200 ml.), according to the procedure in Journal of the American Chemical Society, Vol. 84, page 867 (1962) and Vol. 87, page 1353 (1965). After one hour, the solution was poured into 1 liter of water and the product extracted with ether (3 × 300 ml.). The extract was washed with water (2 × 150 ml.) dried (MgSO4) and evaporated to give an oil, 1,2-epoxy-4-phenylbutane, used directly in the next step.

후처리

  1. extractionthe product extracted with ether (3 × 300 ml.)
  2. washThe extract was washed with water (2 × 150 ml.)
  3. dry with materialdried (MgSO4)
  4. customevaporated

출처 및 근거

ORD 기록
ord-b912e908b32f491b9473384849b9421a
출처 데이터셋
uspto-grants-1977_08
특허 번호
US04045568

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