Hydrochloric Acid → HCID 21193379, 화합물

HRID 443230노트

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HRID 443230 반응식
C[O:2][C:3](=[O:38])[CH:4]([C:14]1[N:15]=[CH:16][N:17]([C:19]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:18]=1)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=1.[OH-].[Li+].Cl>C1COCC1>[C:32]1([C:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[N:17]2[CH:18]=[C:14]([CH:4]([CH2:5][C:6]3[CH:11]=[CH:10][C:9]([C:12]#[N:13])=[CH:8][CH:7]=3)[C:3]([OH:38])=[O:2])[N:15]=[CH:16]2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 54160280HCID 54160280, 화합물

생성물 1

HCID 21193379HCID 21193379, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of the 2-{1-(triphenylmethyl)-1H-imidazol-4-yl}-2-(4-cyanobenzyl)-acetic acid methyl ester in THF was treated with 1 equivalent of 1M lithium hydroxide solution. Upon consumption of starting material as determined by t.l.c, 1 equivalent of hydrochloric acid was added and the solution evaporated to dryness in vacuo. The material obtained in this manner could be used without furthur purification.

후처리

  1. customUpon consumption of starting material
  2. additionwas added
  3. customthe solution evaporated to dryness in vacuo
  4. customThe material obtained in this manner
  5. customcould be used without furthur purification

출처 및 근거

ORD 기록
ord-5d7ebbb555c343a3851f2f9e766b6a0f
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891889

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