Diisopropylamine → 2-(2-Hydroxy-2-p-methoxyphenylethyl)-6-methylpyrazine

HRID 443333

반응식

HRID 443333 반응식
C(NC(C)C)(C)C.C([Li])CCC.[CH3:13][C:14]1[CH:19]=[N:18][CH:17]=[C:16]([CH3:20])[N:15]=1.[CH3:21][O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=[O:28])=[CH:25][CH:24]=1>CCOCC.CCCCCC.O>[OH:28][CH:27]([C:26]1[CH:29]=[CH:30][C:23]([O:22][CH3:21])=[CH:24][CH:25]=1)[CH2:13][C:14]1[CH:19]=[N:18][CH:17]=[C:16]([CH3:20])[N:15]=1

참가 물질

8

반응물 4

HCID 7912DiisopropylamineHCID 79382,6-DimethylpyrazineHCID 312444-MethoxybenzaldehydeHCID 178418339Butyllithium

생성물 1

HCID 5727552-(2-Hydroxy-2-p-methoxyphenylethyl)-6-methylpyrazine

시약·촉매·용매 3

HCID 962Water용매HCID 3283Diethyl Ether용매3회HCID 8058Hexane용매

실험 절차

A solution of 5.05 grams (50 mmole) of diisopropylamine in 40 milliliters of ether was added to 47.1 mole butyllithium in hexane at 0° C. After stirring the resulting solution for 15 minutes, 5.4 grams (50 mmole) of 2,6-dimethylpyrazine in 50 milliliters of ether were added slowly and the reaction mixture was stirred at 0° C. for 30 minutes. A solution of 5.4 grams (40 mmole) of p-methoxybenzaldehyde in 40 milliliters of ether was added, and stirring at 0° C. was continued for an additional 30 minutes. Water was added, the organic phase was separated, washed with water and dried over magnesium sulfate.

후처리

  1. stirringthe reaction mixture was stirred at 0° C. for 30 minutes
  2. stirringstirring at 0° C.
  3. waitwas continued for an additional 30 minutes
  4. customthe organic phase was separated
  5. washwashed with water
  6. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-b78624bf854a48b6ac2689b539b97161
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04259969

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