Hydrazinecarboxaldehyde → 6-(3-Pyridinyl)-1,2,4-triazolo[4,3-b]pyridazine

HRID 443512

반응식

HRID 443512 반응식
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1.[CH:14]([NH:16][NH2:17])=O>C(O)CCC>[N:10]1[CH:11]=[CH:12][CH:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]3[N:3]([CH:14]=[N:16][N:17]=3)[N:4]=2)[CH:9]=1

참가 물질

4

반응물 2

HCID 12229HydrazinecarboxaldehydeHCID 167324353-Chloro-6-(pyridin-3-yl)pyridazine

생성물 1

HCID 142879776-(3-Pyridinyl)-1,2,4-triazolo[4,3-b]pyridazine

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of 1.5 g. of 3-chloro-6-(3-pyridyl)pyridazine and 0.96 g. of formic acid hydrazide in 50 ml. of n-butyl alcohol is refluxed for 48 hours. The reaction mixture is concentrated, partitioned and crystallized as described in Example 1 to afford 1.0 g. of the product of the Example as a cream colored solid, m.p. 199°-200°.

후처리

  1. additionA mixture of 1.5 g
  2. concentrationThe reaction mixture is concentrated
  3. custompartitioned
  4. customcrystallized
  5. customto afford 1.0 g

출처 및 근거

ORD 기록
ord-8179f5fda6934fe5921f263e191122e3
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04260756

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