Nitrourea → Diethyl 2-(3-hydroxy-3-(p-biphenylyl)-propylamino)nonanedioate

HRID 444036

반응식

HRID 444036 반응식
[O:1]=[C:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH2:3][CH2:4][NH:5][CH:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:7]([O:9][CH2:10][CH3:11])=[O:8].C(C(C=C)=O)=C.[N+](NC(N)=O)([O-])=O>C(O)C>[OH:1][CH:2]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)[CH2:3][CH2:4][NH:5][CH:6]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[C:7]([O:9][CH2:10][CH3:11])=[O:8]

참가 물질

5

반응물 3

HCID 62372NitroureaHCID 5431991,4-Pentadien-3-oneHCID 70578184Diethyl 2-(3-oxo-3-(p-biphenylyl)propylamino)nonanedioate

생성물 1

HCID 70510532Diethyl 2-(3-hydroxy-3-(p-biphenylyl)-propylamino)nonanedioate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of diethyl 2-(3-hydroxy-3-(p-biphenylyl)-propylamino)nonanedioate (5 g), which was prepared via diethyl 2-(3-oxo-3-(p-biphenylyl)propylamino)nonanedioate from the appropriate vinyl ketone using the procedure of Example 2, in absolute ethanol (20 ml) was heated at 60° while nitrourea (1.12 g) was added portion-by-portion.

후처리

  1. additionwas added portion-by-portion

출처 및 근거

ORD 기록
ord-7d53ce85b93c416e9ea091733dd1cfec
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04262128

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