1-Chloro-4-nitrobenzene → 1-Methyl-4-[2-(4-nitrophenoxy)ethyl]benzene

HRID 444175

반응식

HRID 444175 반응식
[H-].[Na+].[CH3:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][OH:12])=[CH:6][CH:5]=1.[N+:13]([C:16]1[CH:21]=[CH:20][C:19](Cl)=[CH:18][CH:17]=1)([O-:15])=[O:14]>CS(C)=O>[CH3:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][O:12][C:19]2[CH:20]=[CH:21][C:16]([N+:13]([O-:15])=[O:14])=[CH:17][CH:18]=2)=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 74741-Chloro-4-nitrobenzeneHCID 24758Sodium hydrideHCID 952944-Methylphenethyl alcohol

생성물 1

HCID 51429261-Methyl-4-[2-(4-nitrophenoxy)ethyl]benzene수율 89.4%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
30 °C

실험 절차

To a solution of 65% sodium hydride (1.1 g, 0.03 mole) in dimethylsulfoxide (30 ml) were added 2-(4-methylphenyl)ethyl alcohol (VIII) (2.72 g, 0.02 mole) and 4-nitrochlorobenzene (IX: X=Cl) (3.15 g, 0.02 mole). After heating to 30° C. for 5 hours with stirring, the reaction mixture was treated in the same manner as in Example 12 to obtain 4.6 g of 4-[2-(4-methylphenyl)ethoxy]nitrobenzene (VI) as white crystals (yield, 89.5%).

후처리

  1. additionthe reaction mixture was treated in the same manner as in Example 12
  2. customto obtain

출처 및 근거

ORD 기록
ord-68c853b477e7413a8acfb7aa86d78478
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263219

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