Triphenylphosphine → Phosphonium, (1,2-diethoxy-2-oxoethyl)triphenyl-, chloride (1:1)

HRID 445852

반응식

HRID 445852 반응식
[CH2:1]([O:3][C:4](=[O:10])[CH:5]([Cl:9])[O:6][CH2:7][CH3:8])[CH3:2].[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(Cl)(Cl)Cl>[Cl-:9].[CH2:7]([O:6][CH:5]([P+:17]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:4]([O:3][CH2:1][CH3:2])=[O:10])[CH3:8]

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 2724873Ethyl 2-chloro-2-ethoxyacetate

생성물 1

HCID 11327835Phosphonium, (1,2-diethoxy-2-oxoethyl)triphenyl-, chloride (1:1)수율 82%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 2-chloro-2-ethoxyacetic acid ethyl ester (10 g, 60 mmol) in chloroform (30 mL) was added triphenylphosphine (15.7 g, 60 mmol) and stirred overnight at room temperature. The solvent was removed in vacuo, and diethyl ether was added. The solvent was again removed and dried on high vacuum to give (1,2-diethoxy-2-oxoethyl)triphenylphosphonium chloride (21 g, 82% yield) (679) as a foamy solid.

후처리

  1. customThe solvent was removed in vacuo, and diethyl ether
  2. additionwas added
  3. customThe solvent was again removed
  4. customdried on high vacuum

출처 및 근거

ORD 기록
ord-2b9a860869ac44618919f38e159b26dd
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476308B2

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