Hydrochloric Acid → (1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

HRID 44652

반응식

HRID 44652 반응식
C(OC([NH:8][C@@:9]([CH3:24])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)=[O:11])=O)(C)(C)C.[ClH:25]>O1CCOCC1>[ClH:25].[CH3:24][C@:9]([NH2:8])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:10]([N:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17]1)=[O:11]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57444165tert-butoxycarbonyl-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine

생성물 1

HCID 57444166(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of 630 mg (1.884 mmol) of N-(tert-butoxycarbonyl)-(1S)-1-methyl-2-morpholin-4-yl-2-oxo-1-phenylethylamine in 20 mL of dioxane was treated with 2.5 mL of HCl 4N in dioxane overnight. The solvent was removed under vacuo and the solid was triturated with diethylether yielding 560 mg of the title compound.

후처리

  1. customThe solvent was removed under vacuo
  2. customthe solid was triturated with diethylether yielding 560 mg of the title compound

출처 및 근거

ORD 기록
ord-015e1834be00428fb7598a2baa2a1816
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541429B2

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