Hydrochloric Acid → 2-({6-[(2-{4-[(Biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)-1,3-thiazole-5-carboxylic acid

HRID 446620노트

반응식

HRID 446620 반응식
[OH-].[Na+].C([C:5]1[N:6]=[C:7]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([N:21]([CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][CH:28]([O:31][C:32](=[O:46])[NH:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=3[C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[CH2:27][CH2:26]2)[CH3:22])=[O:20])[S:8][C:9]=1[C:10]([OH:12])=[O:11])C.Cl>C(O)C>[C:35]1([C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=1[NH:33][C:32]([O:31][CH:28]1[CH2:27][CH2:26][N:25]([CH2:24][CH2:23][N:21]([CH3:22])[C:19](=[O:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:7]2[S:8][C:9]([C:10]([OH:12])=[O:11])=[CH:5][N:6]=2)[CH2:30][CH2:29]1)=[O:46]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86663484Ethyl 2-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)-1,3-thiazole-5-carboxylic acid

생성물 1

HCID 866634832-({6-[(2-{4-[(Biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)-1,3-thiazole-5-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A 10 N aqueous sodium hydroxide solution (27 μL) was added to a solution of the compound obtained in Example 104a in ethanol (3.0 mL), and the mixture was stirred at room temperature for 16 hours. The mixture was ice cooled, then a 6 N aqueous hydrochloric acid solution (453 μL, 1) was added, and then the solvent was evaporated under reduced pressure. Methanol (2 mL) and toluene (10 mL) were added to the residue, and the solvent was evaporated under reduced pressure again to give crude 2-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)-1,3-thiazole-5-carboxylic acid (357 mg).

후처리

  1. temperaturecooled
  2. customthe solvent was evaporated under reduced pressure
  3. additionMethanol (2 mL) and toluene (10 mL) were added to the residue
  4. customthe solvent was evaporated under reduced pressure again

출처 및 근거

ORD 기록
ord-f4372ce8f5b14f4480c4e8439ff6ee3c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476253B2

반응 노트

불러오는 중…