Hydrochloric Acid → (6-Methylpyridin-2-yl)methanol hydrochloride

HRID 446815

반응식

HRID 446815 반응식
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[N:7]=1)(=O)C.[ClH:13]>>[ClH:13].[CH3:12][C:8]1[N:7]=[C:6]([CH2:5][OH:4])[CH:11]=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 291137(6-Methylpyridin-2-yl)methyl acetate

생성물 1

HCID 18413908(6-Methylpyridin-2-yl)methanol hydrochloride

실험 절차

A solution of (6-methylpyridin-2-yl)methyl acetate (1.0 g) in concentrated HCl (3 mL) was refluxed for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene, and the residue obtained was filtered and dried in vacuo to afford (6-methylpyridin-2-yl)methanol hydrochloride (811 mg) as a solid.

후처리

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto obtain the crude product
  3. customThe crude material was azeotroped with toluene
  4. customthe residue obtained
  5. filtrationwas filtered
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-fbf72e3296044ccb8ffa6a04d73dd71d
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08481534B2

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